AustralieFrV1, Main, Exploration, bibRecord, 005E17

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

Identifieur interne : 005E17 ( Main/Exploration ); précédent : 005E16; suivant : 005E18

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

Auteurs : Magalj Terme [France] ; Evelyn Ulirichl [France, Allemagne] ; Laetitia Aymeric [France] ; Kathrin Meinhardt [Allemagne] ; Jerome D. Coudert [Australie] ; Melanie Desbois [France] ; François Ghiringhelli [France] ; Sophie Viaud [France] ; Bernard Ryffel [France] ; Hideo Yagita [Japon] ; LIEPING CHEN [États-Unis] ; Salaheddine Mecheri [France] ; Gilles Kaplanski [France] ; Armelle Prevost-Blondel [France] ; Masashi Kato [Japon] ; Joachim L. Schultze [Allemagne] ; Eric Tartour [France] ; Guido Kroemer [France] ; Mariapia Degli-Esposti [Australie] ; Nathalie Chaput [France] ; Laurence Zitvogel [France]

Source :

Cancer research : (Baltimore) [ 0008-5472 ] ; 2012.

RBID : Pascal:12-0250610

Descripteurs français

Pascal (Inist)
- Tumeur maligne, Immunodépression, Interleukine 18, Cytokine, Cellule NK.

English descriptors

KwdEn :
- Cytokine, Immunosuppression, Interleukin 18, Malignant tumor, Natural killer cell.

Abstract

During cancer development, a number of regulatory cell subsets and immunosuppressive cytokines subvert adaptive immune responses. Although it has been shown that tumor-derived interleukin (IL)-18 participates in the PD-1-dependent tumor progression in NK cell-controlled cancers, the mechanistic cues underlying this immunosuppression remain unknown. Here, we show that IL-18 converts a subset of Kit^- (CD11b^-) into Kit⁺ natural killer (NK) cells, which accumulate in all lymphoid organs of tumor bearers and mediate immunoablative functions. Kit⁺ NK cells overexpressed B7-H1/PD-L1, a ligand for PD-1. The adoptive transfer of Kit⁺ NK cells promoted tumor growth in two pulmonary metastases tumor models and significantly reduced the dendritic and NK cell pools residing in lymphoid organs in a B7-Hl-dependent manner. Neutralization of IL-18 by RNA interference in tumors or systemically by IL-18-binding protein dramatically reduced the accumulation of Kit⁺CD11b^- NK cells in tumor bearers. Together, our findings show that IL-18 produced by tumor cells elicits Kit⁺CD11b^- NK cells endowed with B7-H1-dependent immunoablative functions in mice.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001284
to stream PascalFrancis, to step Curation: 004C32
to stream PascalFrancis, to step Checkpoint: 001304
to stream Main, to step Merge: 006139
to stream Main, to step Curation: 005E17

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells</title>
<author><name sortKey="Terme, Magalj" sort="Terme, Magalj" uniqKey="Terme M" first="Magalj" last="Terme">Magalj Terme</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>INSERM U970, PARCC (Paris Cardiovascular Research Center), Université Paris-Descartes</s1>
<s2>Sorbonne Paris Cite</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cite</wicri:noRegion>
<wicri:noRegion>Université Paris-Descartes</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
<orgName type="institution" wicri:auto="newGroup">Sorbonne Paris Cité</orgName>
</affiliation>
</author>
<author><name sortKey="Ulirichl, Evelyn" sort="Ulirichl, Evelyn" uniqKey="Ulirichl E" first="Evelyn" last="Ulirichl">Evelyn Ulirichl</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</s1>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
<wicri:noRegion>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meinhardt, Kathrin" sort="Meinhardt, Kathrin" uniqKey="Meinhardt K" first="Kathrin" last="Meinhardt">Kathrin Meinhardt</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</s1>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
<wicri:noRegion>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coudert, Jerome D" sort="Coudert, Jerome D" uniqKey="Coudert J" first="Jerome D." last="Coudert">Jerome D. Coudert</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia; Australia & Centre for Experimental Immunology, Lions Eye Institute</s1>
<s2>Nedlands, Western Australia</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Nedlands, Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Desbois, Melanie" sort="Desbois, Melanie" uniqKey="Desbois M" first="Melanie" last="Desbois">Melanie Desbois</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center of Clinical Investigations CBT507, Biotherapy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Biotherapy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Viaud, Sophie" sort="Viaud, Sophie" uniqKey="Viaud S" first="Sophie" last="Viaud">Sophie Viaud</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ryffel, Bernard" sort="Ryffel, Bernard" uniqKey="Ryffel B" first="Bernard" last="Ryffel">Bernard Ryffel</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>CNRS, IEM 2815, Institut Transgénose</s1>
<s2>Orleans</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Orléans</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yagita, Hideo" sort="Yagita, Hideo" uniqKey="Yagita H" first="Hideo" last="Yagita">Hideo Yagita</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Immunology, Juntendo University School of Medicine</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lieping Chen" sort="Lieping Chen" uniqKey="Lieping Chen" last="Lieping Chen">LIEPING CHEN</name>
<affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mecheri, Salaheddine" sort="Mecheri, Salaheddine" uniqKey="Mecheri S" first="Salaheddine" last="Mecheri">Salaheddine Mecheri</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Unité de Biologie des Interactions Hôte-Parasite, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaplanski, Gilles" sort="Kaplanski, Gilles" uniqKey="Kaplanski G" first="Gilles" last="Kaplanski">Gilles Kaplanski</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Service de Médecine Interne, Hôpital de la Conception</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prevost Blondel, Armelle" sort="Prevost Blondel, Armelle" uniqKey="Prevost Blondel A" first="Armelle" last="Prevost-Blondel">Armelle Prevost-Blondel</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Institut Cochin, Université Paris Descartes</s1>
<s2>CNRS (UMR 8104)</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CNRS (UMR 8104)</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
<orgName type="institution" wicri:auto="newGroup">Sorbonne Paris Cité</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1016</s1>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1016</wicri:noRegion>
<wicri:noRegion>INSERM, U1016</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kato, Masashi" sort="Kato, Masashi" uniqKey="Kato M" first="Masashi" last="Kato">Masashi Kato</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University</s1>
<s2>Aichi</s2>
<s3>JPN</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Aichi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L." last="Schultze">Joachim L. Schultze</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Laboratory for Genomics and Immunoregulation, LIMES, University of Bonn</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>INSERM U970, PARCC (Paris Cardiovascular Research Center), Université Paris-Descartes</s1>
<s2>Sorbonne Paris Cite</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cite</wicri:noRegion>
<wicri:noRegion>Université Paris-Descartes</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
<orgName type="institution" wicri:auto="newGroup">Sorbonne Paris Cité</orgName>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Faculté Paris Sud-Université Paris XI</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Orsay</settlement>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Degli Esposti, Mariapia" sort="Degli Esposti, Mariapia" uniqKey="Degli Esposti M" first="Mariapia" last="Degli-Esposti">Mariapia Degli-Esposti</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia; Australia & Centre for Experimental Immunology, Lions Eye Institute</s1>
<s2>Nedlands, Western Australia</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Nedlands, Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chaput, Nathalie" sort="Chaput, Nathalie" uniqKey="Chaput N" first="Nathalie" last="Chaput">Nathalie Chaput</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center of Clinical Investigations CBT507, Biotherapy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Biotherapy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center of Clinical Investigations CBT507, Biotherapy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Biotherapy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0250610</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0250610 INIST</idno>
<idno type="RBID">Pascal:12-0250610</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001284</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004C32</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001304</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001304</idno>
<idno type="wicri:doubleKey">0008-5472:2012:Terme M:cancer:induced:immunosuppression</idno>
<idno type="wicri:Area/Main/Merge">006139</idno>
<idno type="wicri:Area/Main/Curation">005E17</idno>
<idno type="wicri:Area/Main/Exploration">005E17</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells</title>
<author><name sortKey="Terme, Magalj" sort="Terme, Magalj" uniqKey="Terme M" first="Magalj" last="Terme">Magalj Terme</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>INSERM U970, PARCC (Paris Cardiovascular Research Center), Université Paris-Descartes</s1>
<s2>Sorbonne Paris Cite</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cite</wicri:noRegion>
<wicri:noRegion>Université Paris-Descartes</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
<orgName type="institution" wicri:auto="newGroup">Sorbonne Paris Cité</orgName>
</affiliation>
</author>
<author><name sortKey="Ulirichl, Evelyn" sort="Ulirichl, Evelyn" uniqKey="Ulirichl E" first="Evelyn" last="Ulirichl">Evelyn Ulirichl</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</s1>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
<wicri:noRegion>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meinhardt, Kathrin" sort="Meinhardt, Kathrin" uniqKey="Meinhardt K" first="Kathrin" last="Meinhardt">Kathrin Meinhardt</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</s1>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
<wicri:noRegion>Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nürnberg Erlangen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coudert, Jerome D" sort="Coudert, Jerome D" uniqKey="Coudert J" first="Jerome D." last="Coudert">Jerome D. Coudert</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia; Australia & Centre for Experimental Immunology, Lions Eye Institute</s1>
<s2>Nedlands, Western Australia</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Nedlands, Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Desbois, Melanie" sort="Desbois, Melanie" uniqKey="Desbois M" first="Melanie" last="Desbois">Melanie Desbois</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center of Clinical Investigations CBT507, Biotherapy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Biotherapy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Viaud, Sophie" sort="Viaud, Sophie" uniqKey="Viaud S" first="Sophie" last="Viaud">Sophie Viaud</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ryffel, Bernard" sort="Ryffel, Bernard" uniqKey="Ryffel B" first="Bernard" last="Ryffel">Bernard Ryffel</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>CNRS, IEM 2815, Institut Transgénose</s1>
<s2>Orleans</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Orléans</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yagita, Hideo" sort="Yagita, Hideo" uniqKey="Yagita H" first="Hideo" last="Yagita">Hideo Yagita</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Immunology, Juntendo University School of Medicine</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lieping Chen" sort="Lieping Chen" uniqKey="Lieping Chen" last="Lieping Chen">LIEPING CHEN</name>
<affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mecheri, Salaheddine" sort="Mecheri, Salaheddine" uniqKey="Mecheri S" first="Salaheddine" last="Mecheri">Salaheddine Mecheri</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Unité de Biologie des Interactions Hôte-Parasite, Institut Pasteur</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaplanski, Gilles" sort="Kaplanski, Gilles" uniqKey="Kaplanski G" first="Gilles" last="Kaplanski">Gilles Kaplanski</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Service de Médecine Interne, Hôpital de la Conception</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prevost Blondel, Armelle" sort="Prevost Blondel, Armelle" uniqKey="Prevost Blondel A" first="Armelle" last="Prevost-Blondel">Armelle Prevost-Blondel</name>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Institut Cochin, Université Paris Descartes</s1>
<s2>CNRS (UMR 8104)</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CNRS (UMR 8104)</wicri:noRegion>
<wicri:noRegion>Université Paris Descartes</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
<orgName type="institution" wicri:auto="newGroup">Sorbonne Paris Cité</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U1016</s1>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1016</wicri:noRegion>
<wicri:noRegion>INSERM, U1016</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kato, Masashi" sort="Kato, Masashi" uniqKey="Kato M" first="Masashi" last="Kato">Masashi Kato</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University</s1>
<s2>Aichi</s2>
<s3>JPN</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Aichi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L." last="Schultze">Joachim L. Schultze</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Laboratory for Genomics and Immunoregulation, LIMES, University of Bonn</s1>
<s2>Bonn</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>INSERM U970, PARCC (Paris Cardiovascular Research Center), Université Paris-Descartes</s1>
<s2>Sorbonne Paris Cite</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Sorbonne Paris Cite</wicri:noRegion>
<wicri:noRegion>Université Paris-Descartes</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
<orgName type="institution" wicri:auto="newGroup">Sorbonne Paris Cité</orgName>
</affiliation>
</author>
<author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>INSERM, U848</s1>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U848</wicri:noRegion>
<wicri:noRegion>INSERM, U848</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Faculté Paris Sud-Université Paris XI</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Orsay</settlement>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Degli Esposti, Mariapia" sort="Degli Esposti, Mariapia" uniqKey="Degli Esposti M" first="Mariapia" last="Degli-Esposti">Mariapia Degli-Esposti</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia; Australia & Centre for Experimental Immunology, Lions Eye Institute</s1>
<s2>Nedlands, Western Australia</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Nedlands, Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chaput, Nathalie" sort="Chaput, Nathalie" uniqKey="Chaput N" first="Nathalie" last="Chaput">Nathalie Chaput</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center of Clinical Investigations CBT507, Biotherapy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Biotherapy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U1015</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>U1015</wicri:noRegion>
<wicri:noRegion>INSERM, U1015</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center of Clinical Investigations CBT507, Biotherapy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Biotherapy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Cancer research : (Baltimore)</title>
<title level="j" type="abbreviated">Cancer res. : (Baltimore)</title>
<idno type="ISSN">0008-5472</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Cancer research : (Baltimore)</title>
<title level="j" type="abbreviated">Cancer res. : (Baltimore)</title>
<idno type="ISSN">0008-5472</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytokine</term>
<term>Immunosuppression</term>
<term>Interleukin 18</term>
<term>Malignant tumor</term>
<term>Natural killer cell</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tumeur maligne</term>
<term>Immunodépression</term>
<term>Interleukine 18</term>
<term>Cytokine</term>
<term>Cellule NK</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">During cancer development, a number of regulatory cell subsets and immunosuppressive cytokines subvert adaptive immune responses. Although it has been shown that tumor-derived interleukin (IL)-18 participates in the PD-1-dependent tumor progression in NK cell-controlled cancers, the mechanistic cues underlying this immunosuppression remain unknown. Here, we show that IL-18 converts a subset of Kit<sup>-</sup>
 (CD11b<sup>-</sup>
) into Kit<sup>+</sup>
 natural killer (NK) cells, which accumulate in all lymphoid organs of tumor bearers and mediate immunoablative functions. Kit<sup>+</sup>
 NK cells overexpressed B7-H1/PD-L1, a ligand for PD-1. The adoptive transfer of Kit<sup>+</sup>
 NK cells promoted tumor growth in two pulmonary metastases tumor models and significantly reduced the dendritic and NK cell pools residing in lymphoid organs in a B7-Hl-dependent manner. Neutralization of IL-18 by RNA interference in tumors or systemically by IL-18-binding protein dramatically reduced the accumulation of Kit<sup>+</sup>
CD11b<sup>-</sup>
 NK cells in tumor bearers. Together, our findings show that IL-18 produced by tumor cells elicits Kit<sup>+</sup>
CD11b<sup>-</sup>
 NK cells endowed with B7-H1-dependent immunoablative functions in mice.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Japon</li>
<li>États-Unis</li>
</country>
<region><li>Centre-Val de Loire</li>
<li>District de Cologne</li>
<li>Maryland</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Région Centre</li>
<li>Région de Kantō</li>
<li>Île-de-France</li>
</region>
<settlement><li>Bonn</li>
<li>Marseille</li>
<li>Orléans</li>
<li>Orsay</li>
<li>Paris</li>
<li>Tokyo</li>
</settlement>
<orgName><li>Sorbonne Paris Cité</li>
<li>Université Paris-Descartes</li>
<li>Université Paris-Sud</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Terme, Magalj" sort="Terme, Magalj" uniqKey="Terme M" first="Magalj" last="Terme">Magalj Terme</name>
</noRegion>
<name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<name sortKey="Aymeric, Laetitia" sort="Aymeric, Laetitia" uniqKey="Aymeric L" first="Laetitia" last="Aymeric">Laetitia Aymeric</name>
<name sortKey="Chaput, Nathalie" sort="Chaput, Nathalie" uniqKey="Chaput N" first="Nathalie" last="Chaput">Nathalie Chaput</name>
<name sortKey="Chaput, Nathalie" sort="Chaput, Nathalie" uniqKey="Chaput N" first="Nathalie" last="Chaput">Nathalie Chaput</name>
<name sortKey="Desbois, Melanie" sort="Desbois, Melanie" uniqKey="Desbois M" first="Melanie" last="Desbois">Melanie Desbois</name>
<name sortKey="Desbois, Melanie" sort="Desbois, Melanie" uniqKey="Desbois M" first="Melanie" last="Desbois">Melanie Desbois</name>
<name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name>
<name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name>
<name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name>
<name sortKey="Kaplanski, Gilles" sort="Kaplanski, Gilles" uniqKey="Kaplanski G" first="Gilles" last="Kaplanski">Gilles Kaplanski</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
<name sortKey="Mecheri, Salaheddine" sort="Mecheri, Salaheddine" uniqKey="Mecheri S" first="Salaheddine" last="Mecheri">Salaheddine Mecheri</name>
<name sortKey="Prevost Blondel, Armelle" sort="Prevost Blondel, Armelle" uniqKey="Prevost Blondel A" first="Armelle" last="Prevost-Blondel">Armelle Prevost-Blondel</name>
<name sortKey="Prevost Blondel, Armelle" sort="Prevost Blondel, Armelle" uniqKey="Prevost Blondel A" first="Armelle" last="Prevost-Blondel">Armelle Prevost-Blondel</name>
<name sortKey="Ryffel, Bernard" sort="Ryffel, Bernard" uniqKey="Ryffel B" first="Bernard" last="Ryffel">Bernard Ryffel</name>
<name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name>
<name sortKey="Terme, Magalj" sort="Terme, Magalj" uniqKey="Terme M" first="Magalj" last="Terme">Magalj Terme</name>
<name sortKey="Terme, Magalj" sort="Terme, Magalj" uniqKey="Terme M" first="Magalj" last="Terme">Magalj Terme</name>
<name sortKey="Ulirichl, Evelyn" sort="Ulirichl, Evelyn" uniqKey="Ulirichl E" first="Evelyn" last="Ulirichl">Evelyn Ulirichl</name>
<name sortKey="Viaud, Sophie" sort="Viaud, Sophie" uniqKey="Viaud S" first="Sophie" last="Viaud">Sophie Viaud</name>
<name sortKey="Viaud, Sophie" sort="Viaud, Sophie" uniqKey="Viaud S" first="Sophie" last="Viaud">Sophie Viaud</name>
<name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
<name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Ulirichl, Evelyn" sort="Ulirichl, Evelyn" uniqKey="Ulirichl E" first="Evelyn" last="Ulirichl">Evelyn Ulirichl</name>
</noRegion>
<name sortKey="Meinhardt, Kathrin" sort="Meinhardt, Kathrin" uniqKey="Meinhardt K" first="Kathrin" last="Meinhardt">Kathrin Meinhardt</name>
<name sortKey="Schultze, Joachim L" sort="Schultze, Joachim L" uniqKey="Schultze J" first="Joachim L." last="Schultze">Joachim L. Schultze</name>
</country>
<country name="Australie"><noRegion><name sortKey="Coudert, Jerome D" sort="Coudert, Jerome D" uniqKey="Coudert J" first="Jerome D." last="Coudert">Jerome D. Coudert</name>
</noRegion>
<name sortKey="Degli Esposti, Mariapia" sort="Degli Esposti, Mariapia" uniqKey="Degli Esposti M" first="Mariapia" last="Degli-Esposti">Mariapia Degli-Esposti</name>
</country>
<country name="Japon"><region name="Région de Kantō"><name sortKey="Yagita, Hideo" sort="Yagita, Hideo" uniqKey="Yagita H" first="Hideo" last="Yagita">Hideo Yagita</name>
</region>
<name sortKey="Kato, Masashi" sort="Kato, Masashi" uniqKey="Kato M" first="Masashi" last="Kato">Masashi Kato</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Lieping Chen" sort="Lieping Chen" uniqKey="Lieping Chen" last="Lieping Chen">LIEPING CHEN</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005E17 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005E17 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0250610
   |texte=   Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri